Biography
Dr. Shi-Qiang Wang received his B.S. and Ph.D. degrees from College of Life Sciences, Peking University, China in 1990 and 1998, respectively. In 2003, he completed postdoctoral research in National Institute on Aging, NIH, USA, and retuned to Peking University. In 2005, he was honored as a Cheung Kong Scholar Professor by the Ministry of Education. Dr. Wang’s studies have been focused on the molecular basis of intracellular Ca2+ signaling. He combines state-of-the-art confocal imaging, single-channel patch clamping, single-molecule tracing with molecular cell biology techniques to dissect the molecular mechanisms underlying the generation, amplification and termination of intracellular Ca2+ dynamics, aiming to answer important questions about the function, development and dysfunction of the heart. Many of his work were published in high profile journals, including Nature, PLoS Biology, PNAS and Circulation Research. He gained a number of nationally and internationally-recognized awards and prizes, such as the Chang Hsi-chun Young Investigator Prize by Chinese Association for Physiological Sciences (1997), the Richard J. Bing Young Investigator Award by International Society for Heart Research (2001), the Katz Basic Science Research Prize by American Heart Association (2002),and the National Natural Science Prize of China (2017).
Education
1999.1 - 2003.11, Postdoctoral fellow and Research Associate, National Institute on Aging, NIH
1992.9 - 1998.7, Ph.D., Physiology, Peking University
1986.9 - 1990.7, B.S., Physiology & Biophysics, Peking University
Professional Experience
2003.8 - present, Professor, College of Life Sciences, Peking University
1999.7 - 2003.7, Associate Professor, College of Life Sciences, Peking University
1994.7 - 1999.6, Lecturer, College of Life Sciences, Peking University
1990.8 - 1994.6, Assistant Lecturer, Department of Biology, Peking University
Molecular mechanism of calcium signaling
Ca2+ is a universal intracellular messenger, playing pivotal roles in nearly all biological processes. We combine state-of-the-art molecular imaging, single-channel patch clamping, electron microscopy and molecular cell biology techniques to dissect the molecular mechanisms underlying the generation, amplification and termination of intracellular Ca2+ dynamics, aiming to answer important questions about the function, development and dysfunction of heart cells.
1. Guo QJ, Liang JH, Li HT, Li LL, Guo Y, Wang LP, Ma XL, Xie XJ, Hou T, Wang SQ* (2025) Early-Stage Morphogenesis of T-Tubules in Rat Cardiomyocytes: The Role of pBIN1. Circ. Res. , doi: 10.1161/CIRCRESAHA.124.325472. PMID: 40509990
2. Gu W, Chen JH, Zhang Y, Wang Z, Li J, Wang S, Zhang H, Jiang A, Zhong Z, Zhang J, Xu Z, Liu P, Xi C, Hou T, Gill DL, Li D, Mu Y, Wang SQ*, Tang AH*, Wang Y* (2025) Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells. Nat. Commun. , 16:3472. doi: 10.1038/s41467-025-58705-6. PMID: 40216787
3. Guo QJ, Hou TT, Xie WJ, Zhang JR, Ma XL, Guo YN, Wang XT, Wang LP, Lu MA, Wu ZF, Wang HG, Chen YH, Li YL, Wang SQ*. Calcium homeostasis modulator 2 constitutes an ATP-regulation pore in mitochondria. bioRxiv, 10.1101/2024.09.30.6159833.
4. Wu Z, Shi Y, Cui Y, Xing X, Zhang L, Liu D, Zhang Y, Dong J, Jin L, Pang M, Xiao RP, Zhu Z, Xiong JW, Tong X, Zhang Y, Wang SQ*, Tang F*, Zhang B* (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein Cell. , 14:350-368. doi: 10.1093/procel/pwac010. PMID: 37155312
5. Yang L, Li RC, Xiang B, Li YC, Wang LP, Guo YB, Liang JH, Wang XT, Hou T, Xing X, Zhou ZQ, Ye H, Feng RQ, Lakatta EG, Chai Z, Wang SQ* (2021) Transcriptional regulation of intermolecular Ca2+ signaling in ground squirrel cardiomyocytes: the myocardin- junctophilin axis. Proc. Natl. Acad. Sci. U.S.A. , 118:e2025333118. doi: 10.1073/pnas.2025333118. PMID: 33785600
6. Li LL, Guo QJ, Luo HY, Liang JH, Yang Y, Xing X, Li HT, Han J, Shen S, Li H, Ye HH, Wu HD, Cui BX*, Wang SQ* (2020) Nanobar Array Assay Revealed Complementary Roles of BIN1 Splice Isoforms in Cardiac T-Tubule Morphogenesis. Nano Letters, 20:6387-6395. doi: 10.1021/acs.nanolett.0c01957. PMID: 32787151 [Cover story]
7. Yang HQ, Zhou P, Wang LP, Zhao YT, Ren YJ, Guo YB, Xu M, Wang SQ* (2020) Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes. Cardiov. Res. , 116:2069-2080. doi: 10.1093/cvr/cvaa013. PMID: 32031586 [Commentary: Cardiov. Res. 116:2033–2035]
8. Yang HQ, Wang LP, Gong Y, Fan XX, Zhu SY, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou T, Zhang Y, Xiao RP, Wang SQ* (2019) β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ. Res. , 124:1350-1359. doi: 10.1161/CIRCRESAHA.118.314322. PMID: 30836825 [Highlighted & Cover story]
9. Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji G, Wang SQ (2017) Sensitized signaling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. Cardiov. Res. , 113:332-342. doi: 10.1093/cvr/cvw247. PMID: 28077437 [Commentary: Cardiov. Res.113, 256–258]
10. Shang W, Lu F, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ*, Cheng H* (2014) Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor. Cir. Res. , 114:412-420. doi: 10.1161/CIRCRESAHA.114.302938. PMID: 24257462 [Commentary: Circ. Res.114:412-420]
11. Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ* (2013) In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice. Circ. Res. , 112:601-605. doi: 10.1161/CIRCRESAHA.112.300806. PMID: 23307820 [Li Rongchang, Award for Excellent Paper, Zhang Xijun Fund of the Chinese Physiological Society, 2013]
12. Zhang HB, Li RC, Xu M, Xu SM, Lai YS, Wu HD, Xie XJ, Gao W, Ye H, Zhang YY, Meng X, Wang SQ* (2013) Ultrastructural Uncoupling between T-tubules and Sarcoplasmic Reticulum in Human Heart Failure. Cardiov. Res. , 98:269-276. doi: 10.1093/cvr/cvt030. PMID: 23405000 [Cover story]
13. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JZ J., Gao W, Han QD, Zhang YY, Wang XJ*, Meng X, and Wang SQ* (2012) MiR-24 regulates junctophilin-2 expression in cardiomyocytes. Circ. Res. , 111:837-841. doi: 10.1161/CIRCRESAHA.112.277418. PMID: 22891046 [Commentary: Circ. Res.111:816-818]
14. Wu HD, Xu M, Li RC, Guo L, Lai YS, Xu SM, Li ll, Lü QL, Zhang HB, Zhang YY, Zhang CM and Wang SQ* (2012) Ultrastructural Remodeling of Ca2+ Signaling Apparatus in Failing Heart Cells. Cardiov. Res. , 95:430-438. doi: 10.1093/cvr/cvs195. PMID: 22707157 [Commentary: Cardiov. Res. 95:397-398]
15. Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, Cheng H, Hao XM, Wang SQ* (2009) Beta-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc. Natl. Acad. Sci. U. S. A. , 106:18028-18033. doi: 10.1073/pnas.0906560106. PMID: 19815510 [Zhou Peng, IUPhar Young Investigator Award, IUPHAR, 2006]
16. Tang AH, Wang SQ* (2009) Transition of spiral calcium waves between multiple stable patterns can be triggered by a single calcium spark in a fire-diffuse-fire model. Chaos , 19:037114. doi: 10.1063/1.3207814. PMID: 19792039
17. Xu M, Zhou P, Xu SM, Liu Y, Feng XH, Bai SH, Bai Y, Hao XM, Han QD, Zhang YY*, Wang SQ* (2007) Intermolecular Failure of L-type Ca2+ Channel and Ryanodine Receptor Signaling in Hypertrophy. PLoS Biol. , 5: e21,0203-0211. doi: 10.1371/journal.pbio.0050021. PMID: 17214508 [Highlighted: Heart disease: Unmasking molecular mechanisms. Nat. Rev. Drug Disc. , 6: 271] [2007 Award for Highly Influential Cardiovascular Papers in China]
18. Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ*, Chai Z* (2006) Interleukin-1b downregulates the L-Type Ca channel activity by depressing the expression of channel protein in cortical neurons. J. Cell. Physiol. , 206:799-806. doi: 10.1002/jcp.20518. PMID: 16222709 [Zhou Chen, Award for Excellent Paper, Zhang Xijun Fund of the Chinese Physiological Society, 2006]
19. Wang SQ, Stern MD, Ríos E, Cheng H (2004) The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array. Proc. Natl. Acad. Sci. U. S. A. , 101: 3979-3984. doi: 10.1073/pnas.0306157101. PMID: 15004280 [2002 Katz Basic Science Research Prize, American Heart Association (AHA)]
20. Wang SQ ,Song LS, Lakatta EG, Cheng H (2001) Ca2+ signaling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature , 410:592-596. doi: 10.1038/35069083. PMID: 11279498 [2001 Richard Bing Prize, International Society for Heart Research (ISHR)]
